Research Reports - Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury
Restor Neurol Neurosci. 2015 Nov 4;33(6):943-51. doi: 10.3233/RNN-150585.
Tal S(1,)(2), Hadanny A(3,)(1), Berkovitz N(1,)(2), Sasson E(4), Ben-Jacob
E(5,)(6,)(7), Efrati S(3,)(1,)(5,)(6).
PURPOSE: Recent clinical studies present convincing evidence that hyperbaric
oxygen therapy (HBOT) may be the coveted neurotherapeutic method for brain
repair. One of the most interesting ways in which HBOT can induce neuroplasticity
is angiogenesis.The objective in this study was to assess the neurotherapeutic
effect of HBOT in post TBI patients using brain perfusion imaging and clinical
METHODS: Retrospective analysis of patients suffering from chronic
neuro-cognitive impairment from TBI treated with HBOT. The HBOT protocol included
60 daily HBOT sessions, 5 days per week. All patients had pre and post HBOT
objective computerized cognitive tests (NeuroTrax) and brain perfusion MRI.
RESULTS: Ten post-TBI patients were treated with HBOT with mean of 10.3±3.2 years
after their injury. After HBOT, whole-brain perfusion analysis showed
significantly increased cerebral blood flow and cerebral blood volume.
Clinically, HBOT induced significant improvement in the global cognitive scores
(p = 0.007). The most prominent improvements were seen in information processing
speed, visual spatial processing and motor skills indices.
CONCLUSION: HBOT may induce cerebral angiogenesis, which improves perfusion to
the chronic damage brain tissue even months to years after the injury.