Research Reports - Traumatic brain injury and substance related disorder
Neural Plast. 2016;2016:8030676. Epub 2016 Sep 27.
Wu CH(1), Tsai TH(2), Su YF(2), Zhang ZH(3), Liu W(4), Wu MK(5), Chang CH(2), Kuo
KL(2), Lu YY(6), Lin CL(7).
Whether traumatic brain injury (TBI) is causally related to substance related
disorder (SRD) is still debatable, especially in persons with no history of
mental disorders at the time of injury. This study analyzed data in the Taiwan
National Health Insurance Research Database for 19,109 patients aged ≥18 years
who had been diagnosed with TBI during 2000-2010. An additional 19,109 randomly
selected age and gender matched patients without TBI (1 : 1 ratio) were enrolled
in the control group. The relationship between TBI and SRD was estimated with Cox
proportional hazard regression models. During the follow-up period, SRD developed
in 340 patients in the TBI group and in 118 patients in the control group. After
controlling for covariates, the overall incidence of SRD was 3.62-fold higher in
the TBI group compared to the control group. Additionally, patients in the severe
TBI subgroup were 9.01 times more likely to have SRD compared to controls.
Notably, patients in the TBI group were prone to alcohol related disorders. The
data in this study indicate that TBI is significantly associated with the
subsequent risk of SRD. Physicians treating patients with TBI should be alert to
this association to prevent the occurrence of adverse events.