Research Reports - Effects of cerebrolysin on functional recovery in patients with severe disability after traumatic brain injury

Clin Neurol Neurosurg. 2016 Nov 15;152:34-38. doi:
10.1016/j.clineuro.2016.11.011. [Epub ahead of print]

Khalili H(1), Niakan A(2), Ghaffarpasand F(3).

OBJECTIVE: To determine the effects of cerebrolysin on functional recovery in
patients with severe disability after traumatic brain injury (TBI).
METHODS: This was a retrospective cohort study being performed during a 2-year
period in a level I trauma center in Southern Iran including all the adult
patients (>16years) with severe disability (GOS of 2 and 3) 1-month after trauma.
We excluded those with posttraumatic seizures and those with meningitis or
current infections. Some patients received cerebrolysin (n=65) and some did not
(n=64). Cerebrolysin was administered intravenously in 10mL dosage daily for
30days. Patients in two study groups were matched regarding the baseline
characteristics including age, gender, GCS on admission, pupil reactivity and
Rotterdam score. The administered cerebrolysin dosage was 10mL intravenously
daily for 30days. The 3- and 6-month Glasgow Outcome Scale Extended (GOSE) was
recorded. The outcome scales were compared between two study groups.
RESULTS: Overall we included 129 patients with severe disability 1-month after
TBI. The baseline characteristics were comparable between groups. We found that
GOSE at 3-month (p=0.017) and 6-month (p=0.009) was significantly higher in those
receiving cerebrolysin. Cerebrolysin administration was associated with lower
mortality rate, and higher good recovery after 6 month of therapy (p=0.024).
Cerebrolysin administration was also associated with higher favorable and lower
unfavorable outcome (p=0.043). Cerebrolysin was associated with higher seizure
rate (p=0.042).
CONCLUSION: Cerebrolysin administration in patients with severe disability after
TBI is associated with improved functional recovery, decreased mortality rate and
increased favorable outcome. Seizure is important side effect of cerebrolysin
administration in TBI patients. 

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