Research Reports - Genetic factors influencing outcome from neurotrauma

Curr Opin Psychiatry. 2012 May;25(3):231-8

Dardiotis E, Grigoriadis S, Hadjigeorgiou GM.

PURPOSE OF REVIEW: Clinical outcome after neurotrauma is considerably variable
and can only partly be explained by known prognostic factors. There is converging
evidence from genetic research that a number of genetic variants may contribute
to this variability. This review provides recent data from human studies,
published in the previous year, on genetic factors influencing outcome after
neurotrauma. The bibliographic databases MEDLINE, EMBASE and PsycINFO were
searched to identify relevant studies.
RECENT FINDINGS: Genetic susceptibility to various aspects of clinical outcome
after neurotrauma was reported in recent clinical studies. Genetic loci
investigated include polymorphisms in APOE, MAO-A, BDNF, NOS3, IL-6, NEFH,
SLC6A4, COMT, PPP3CC and KIBRA genes. The importance of these findings and future
directions are discussed.
SUMMARY: Recent genetic studies have revealed emerging aspects and extended the
existing knowledge regarding the pathogenesis of neurotrauma and the genetic
influence on phenotypic diversity. A better understanding of the underlying
biological pathways and molecular mechanisms of an individual's response to
neurotrauma may hold the promise of novel treatment strategies and improved
clinical outcome.

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