Research Reports - Population based study on patients with traumatic brain injury suggests increased risk of dementia
J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1080-5
Wang HK, Lin SH, Sung PS, Wu MH, Hung KW, Wang LC, Huang CY, Lu K, Chen HJ, Tsai KJ
OBJECTIVE: The relationship between traumatic brain injury (TBI) and the risk of
dementia remains controversial. This population based study was designed to
estimate and compare the risk of dementia in TBI and non-TBI individuals during
the 5 year period after TBI.
METHODS: This study was a retrospective cohort study. Data were obtained from the
Longitudinal Health Insurance Database 2000. We included 44 925 patients
receiving ambulatory or hospital care and 224 625 non-TBI patients; patients were
matched for sex, age and year of index use of healthcare. Patients <15 years of
age and those admitted to the intensive care unit were excluded. Each individual
was studied for 5 years to identify the subsequent development of dementia. Data
were analysed by Cox proportional hazard regression.
RESULTS: During the 5 year follow-up period, 1196 TBI (2.66%) and 224 625 non-TBI
patients (1.53%) patients developed dementia. During the 5 year follow-up period,
TBI was independently associated with a 1.68 (range 1.57-1.80) times greater risk
of dementia after adjusting for sociodemographic characteristics and selected
CONCLUSIONS: The findings of this study suggest an increased risk of dementia
among individuals with TBI. We suggest the need for more intensive medical
monitoring and health education in individuals with TBI.