Research Reports - Neuropsychological recovery and quality-of-life in children and adolescents with growth hormone deficiency following TBI
Brain Inj. 2013;27(2):200-8
Wamstad JB, Norwood KW, Rogol AD, Gurka MJ, Deboer MD, Blackman JA, Buck ML, Kuperminc MN, Darring JG, Patrick PD
Objective: To compare neurocognition and quality-of-life (QoL) in a group of
children and adolescents with or without growth hormone deficiency (GHD)
following moderate-to-severe traumatic brain injury (TBI). Study designs:
Thirty-two children and adolescents were recruited from the TBI clinic at a
children's hospital. Growth hormone (GH) was measured by both spontaneous
overnight testing and following arginine/glucagon stimulation administration.
Twenty-nine subjects participated in extensive neuropsychological assessment.
Results: GHD as measured on overnight testing was significantly associated with a
variety of neurocognitive and QoL measures. Specifically, subjects with GHD had
significantly (p < 0.05) lower scores on measures of visual memory and
health-related quality-of-life. These scores were not explained by severity of
injury or IQ (p > 0.05). GHD noted in response to provocative testing was not
associated with any neurocognitive or QoL measures. Conclusions: GHD following
TBI is common in children and adolescents. Deficits in neurocognition and QoL
impact recovery after TBI. It is important to assess potential neurocognitive and
QoL changes that may occur as a result of GHD. It is also important to consider
the potential added benefit of overnight GH testing as compared to stimulation
testing in predicting changes in neurocognition or QoL.