Research Reports - Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients

Br J Neurosurg. 2013 May 8

Chen CC, Wei ST, Tsaia SC, Chen XX, Cho DY

In adults, mild traumatic brain injury (MTBI) frequently results in impairments
of cognitive functions which would lead to psychological consequences in the
future. Cerebrolysin is a nootropic drug, and can significantly improve cognitive
function in patients with Alzheimer's disease and stroke. The purpose of this
study was to investigate how Cerebrolysin therapy enhances cognitive recovery for
mild traumatic brain injury patients using a double-blinded, placebo-controlled,
randomized phase II pilot study. Patients having head injury within 24 h sent to
our hospital were screened and recruited if patients were alert and conscious,
and had intracranial contusion haemorrhage. From July 2009 to June 2010, totally,
thirty-two patients were recruited in the double-blinded, placebo-controlled, and
randomized study. Patients were randomized to receive Cerebrolysin (Group A, once
daily intravenous infusion of 30 mL Cerebrolysin over a 60-min period for 5 days)
or placebo (Group B, same dosage and administration of normal saline as Group A).
The primary outcome measures were differences of cognitive function including
Mini-Mental Status Examination (MMSE), and Cognitive Abilities Screening
Instrument (CASI) scores between baseline and week 1, between baseline and week
4, and between baseline and week 12. Thirty-two patients completed the trial. For
Group A, the CASI score difference between baseline and week 12 was 21.0 ± 20.4,
a significantly greater change than that of Group B (7.6 ± 12.1) (p = 0.0461).
Besides, drawing function (one of the domains of CASI; p = 0.0066) on week 4 and
both drawing function (p = 0.0472) and long-term memory (one of the domains of
CASI; p = 0.0256) on week 12were also found to be significantly improved in the
patients receiving Cerebrolysin treatment. Our results suggest that Cerebrolysin
improves the cognitive function of the MTBI in patients at 3rd month after
injury, especially for long-term memory and drawing function.

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