Research Reports - Effect of progesterone administration on prognosis of patients with diffuse axonal injury due to severe head trauma

Clin Neurol Neurosurg. 2013 Jul 18

Shakeri M, Boustani MR, Pak N, Panahi F, Salehpour F, Lotfinia I, Meshkini A, Daghighi S, Vahedi P, Khani M, Taghiloo D

OBJECTIVE: Severe traumatic brain injury (TBI) has a major role in mortality rate
among the other types of trauma. The aim of this clinical study was to assess the
effect of progesterone on the improvement of neurologic outcome in patients with
acute severe TBI.
METHODS: A total of 76 patients who had arrived within 8h of injury with a
Glasgow Coma Score ≤8 were enrolled in the study. In a randomized style 38
received progesterone (1mg/kg per 12h for 5 days) and 38 did not.
RESULTS: There was a better recovery rate and GOS score for the patients who were
given progesterone than for those in the control group in a 3-months follow-up
period (50% vs. 21%); subgroup analysis showed a significant difference in the
percentage of favorable outcome between the two groups with GCS of 5-8 (p=0.03).
CONCLUSION: The use of progesterone may significantly improve neurologic outcome
of patients suffering severe TBI up to 3 months after injury, especially those
with 5≤GCS≤8, providing a potential benefit to the treatment of acute severe TBI
patients. Considering this drug had no significant side effects, so progesterone
could be used in patients with severe TBI as a neuro-protective drug.

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