Research Reports - Neuroendocrine consequences of traumatic brain injury
Curr Opin Endocrinol Diabetes Obes. 2013 Aug;20(4):354-8
Munoz A, Urban R
PURPOSE OF REVIEW: This article attempts to summarize findings of recent
publications addressing the prevalence, effects, and treatment of pituitary
hormone deficiency following traumatic brain injury (TBI).
RECENT FINDINGS: A number of recent studies of TBI victims offer larger samples
and much longer follow-up times. However, the prevalence of pituitary hormone
deficiency continues to vary widely, underscoring the influence of patient
selection, differences in endocrine testing, and patient's comorbidities and age.
Growth hormone deficiency (GHD) continues to be the most frequently detected type
of pituitary dysfunction. Several reports show the influence of GHD on functional
outcomes of TBI victims beyond what is predicted by trauma severity. Emerging
data support the notion growth hormone (GH) replacement as a useful intervention
to improve symptomatology and functional outcomes among adequately selected
GH-deficient patients recovering from TBI.
SUMMARY: Pituitary dysfunction is prevalent following TBI. Pituitary dysfunction
seems to influence functional outcomes in some patients recovering from brain
injury. Adequately selected patients could benefit from hormonal replacement.