Research Reports - Hypocalcaemia as a prognostic factor of early mortality in traumatic brain injury

Neurol Res. 2013 Oct 17

Vinas-Rios JM, Sanchez-Aguilar M, Sanchez-Rodriguez JJ, Gonzalez-Aguirre D, Heinen C, Meyer F, Kretschmer T

OBJECTIVES: Our main objective was to evaluate whether serum hypocalcaemia on the
third day [defined as, 2.1 mmol/l (8.5 mg/dl)] is a prognostic factor for early
mortality after moderate and severe traumatic brain injury (TBI).METHODS: We
developed an ambispective comparative case control study. We evaluated clinical
profiles from included patients from January 2005 to July 2009 and we
prospectively recruited additional patients from August 2009 to July 2011.
Patients were between 1 and 89 years old and had a Glasgow Coma Scale of 3?12
points following TBI.RESULTS: We calculated an Odds Ratio of 5.2 (Confidence
Intervals 95%: 4.48 to 6.032) for hypocalcaemia on day three, which was
associated with death. Retrospectively (January 2005 to July 2009) we compiled
data from 81 patients. Prospectively (August 2009 to July 2011) we recruited 41
patients. The adjusted variables in the logistic regression final model were:
serum calcium on day three (Odds Ratio 3.5, Confidence Intervals 95%: 1.12 to
13.61, P < 0.028) and anisocoria (Odds Ratio 8.24, Confidence Intervals 95%: 1.3
to 67.35, P < 0.019) obtaining an adjusted R2 of 0.22 (P < 0.005).DISCUSSION: The
serum levels of calcium on day three could be useful for the prediction of
mortality in patients with moderate and severe TBI.

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