Research Reports - Volumetrics relate to the development of depression after traumatic brain injury

Behav Brain Res. 2014 Jun 2;271C:147-153

Maller JJ(1), Thomson RH(2), Pannek K(3), Bailey N(2), Lewis PM(4), Fitzgerald PB(2)

Previous research suggests that many people who sustain a traumatic brain injury
(TBI), even of the mild form, will develop major depression (MD). We previously
reported white matter integrity differences between those who did and did not
develop MD after mild TBI. In this current paper, we aimed to investigate whether
there were also volumetric differences between these groups, as suggested by
previous volumetric studies in mild TBI populations. A sample of TBI-with-MD
subjects (N=14), TBI-without-MD subjects (N=12), MD-without-TBI (N=26) and
control subjects (no TBI or MD, N=23), received structural MRI brain scans.
T1-weighted data were analysed using the Freesurfer software package which
produces automated volumetric results. The findings of this study indicate that
(1) TBI patients who develop MD have reduced volume in temporal, parietal and
lingual regions compared to TBI patients who do not develop MD, and (2) MD
patients with a history of TBI have decreased volume in the temporal region
compared to those who had MD but without a history of TBI. We also found that
more severe MD in those with TBI-with-MD significantly correlated with reduced
volume in anterior cingulate, temporal lobe and insula. These findings suggest
that volumetric reduction to specific regions, including parietal, temporal and
occipital lobes, after a mild TBI may underlie the susceptibility of these
patients developing major depression, in addition to altered white matter
integrity.

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