Research Reports - Increased risk of ischemic stroke in patients with mild traumatic brain injury

Scand J Trauma Resusc Emerg Med. 2014 Nov 19;22(1):66

Lee YK, Lee CW, Huang MY, Hsu CY, Su YC(1)

BACKGROUND: It is known that the risk of stroke in patients with traumatic brain
injury might be increased. However, the relationship between mild traumatic brain
injury and ischemic stroke has never been established. We conducted a study of
patients in Taiwan with mild traumatic brain injury to evaluate if they had a
higher risk of stroke compared with the general population.
METHODS: We utilized a sampled National Health Insurance claims database
containing one million beneficiaries. We followed all adult beneficiaries older
than 18 years from January 1, 2007 to December 31, 2010 to determine if they were
diagnosed with ischemic stroke. We further identified patients with mild
traumatic brain injury and compared their risk of ischemic stroke with the
general population.
RESULTS: We identified 24,905 patients with mild traumatic brain injury and
719,811 patients without mild traumatic brain injury. After controlling for age,
gender, urbanization level, socioeconomic status, diabetes, hypertension,
coronary artery disease, hyperlipidemia, history of alcohol intoxication,
malignancies, heart failure, atrial fibrillation, smoking, obesity, epilepsy,
peripheral artery disease and Charlson Comorbidity Index score, the adjusted
hazard ratio for ischemic stroke was 1.46 (95% confidence interval, 1.33-1.62).
CONCLUSION: Mild traumatic brain injury is an independent significant risk factor
for ischemic stroke.

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